Contributions and future perspectives on the use of magnetic nanoparticles as diagnostic and therapeutic tools in the field of regenerative medicine

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2013

Autores

Santo, VE (Autor) Outra; Rodrigues, MT (Autor) Outra; Gomes, ME (Autor) Outra

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Vol. 13

Páginas: 553-566

ISSN: 1473-7159

Editora: Expert Reviews

Indexação

ISI Web of Knowledge - 20 Citações

Scopus - 26 Citações

Outras Informações

ID Authenticus: P-008-CEN

DOI: 10.1586/14737159.2013.819169

Abstract (EN): The current limitations of regenerative medicine strategies may be overcome through the use of magnetic nanoparticles (MNPs), a class of nanomaterial typically composed of magnetic elements that can be manipulated under the influence of an external magnetic field. Cell engineering approaches following the internalization of these MNPs by cells and/or the incorporation of these nanosystems within 3D constructs (scaffolds or hydrogels) may constitute a new attractive approach to achieve a magnetically responsive system enabling remote control over tissue-engineered constructs in an in vivo scenario. Moreover, the incorporation of bioactive factors within these MNPs also enables a targeted and smart delivery of biomolecules to specific regions and/or triggering specific cell responses upon external magnetic stimulation. Certainly, one of the most attractive properties of MNPs is their ability to be used as theranostic tools for regenerative medicine applications, enabling live monitoring and tracking of the system while simultaneously acting as a therapeutic stimulation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14