Cell Delivery Systems Using Alginate-Carrageenan Hydrogel Beads and Fibers for Regenerative Medicine Applications

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Popa, EG (Autor) Outra; Gomes, ME (Autor) Outra; Rui Reis (Autor) Outra

Revista

Título: Biomacromolecules

Vol. 12

Páginas: 3952-3961

ISSN: 1525-7797

Editora: American Chemical Society

Indexação

ISI Web of Knowledge - 119 Citações

Scopus - 143 Citações

Outras Informações

ID Authenticus: P-002-K03

DOI: 10.1021/bm200965x

Abstract (EN): The present work was focused on the development and characterization of new hydrogel systems based on natural origin polymers, namely, alginate and carrageenan, into different formats and with adequate properties to sustain the viability of encapsulated cells, envisioning their application as cell delivery vehicles for tissue regeneration. Different formulations of alginate and carrageenan hydrogels and different processing parameters were considered to determine the best conditions required to achieve the most adequate response in terms of the mechanical stability, cell viability, and functionality of the developed, systems. The morphology, size, and structure of the hydrogels and their degradation behavior and mechanical properties were evaluated during this study. In addition to cytotoxicity studies, preliminary experiments were carried out to investigate the ability of alginate-carrageenan beads/fibers to encapsulate chondrocytes. The results obtained indicated that the different formulations, both in the form of beads and fibers, have considerable potential as cell-carrier materials for cell delivery in tissue engineering/regenerative medicine applications.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10