Optimized reconstruction of the absorption spectra of kidney tissues from the spectra of tissue components using the least squares method

• Tipo: Artigo em Revista Científica Internacional
• Data: 2024

Autores

Pinheiro, MR (Autor) Outra; Fernandes, LE (Autor) Outra; Carneiro, IC (Autor) Outra; Carvalho, SD (Autor) Outra; Henrique, RM (Autor) Outra; Tuchin, VV (Autor) Outra; Oliveira, HP (Autor) FCUP; Oliveira, LM (Autor) Outra

Revista

Título: Journal of Biophotonics

ISSN: 1864-063X

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 3 Citações

Outras Informações

ID Authenticus: P-00Z-ZEP

DOI: 10.1002/jbio.202300466

Abstract (EN): With the objective of developing new methods to acquire diagnostic information, the reconstruction of the broadband absorption coefficient spectra (mu a[lambda]) of healthy and chromophobe renal cell carcinoma kidney tissues was performed. By performing a weighted sum of the absorption spectra of proteins, DNA, oxygenated, and deoxygenated hemoglobin, lipids, water, melanin, and lipofuscin, it was possible to obtain a good match of the experimental mu a(lambda) of both kidney conditions. The weights used in those reconstructions were estimated using the least squares method, and assuming a total water content of 77% in both kidney tissues, it was possible to calculate the concentrations of the other tissue components. It has been shown that with the development of cancer, the concentrations of proteins, DNA, oxygenated hemoglobin, lipids, and lipofuscin increase, and the concentration of melanin decreases. Future studies based on minimally invasive spectral measurements will allow cancer diagnosis using the proposed approach.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10