Multifunctional Nanoparticles with Superparamagnetic Mn(II) Ferrite and Luminescent Gold Nanoclusters for Multimodal Imaging

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Casteleiro, B (Autor) Outra; Rocha, M (Autor) Outra; Sousa, AR (Autor) Outra; pereira, a. m. (Autor) FCUP; Martinho, JMG (Autor) Outra; Clara Pereira (Autor) FCUP; Farinha, JPS (Autor) Outra

Revista

Título: Polymers

Nº de Série 8 Vol. 10 Nº 810

Página Final: 4392

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Z-ANK

DOI: 10.3390/polym15224392

Abstract (EN): Gold nanoclusters (AuNCs) with fluorescence in the Near Infrared (NIR) by both one- and two-photon electronic excitation were incorporated in mesoporous silica nanoparticles (MSNs) using a novel one-pot synthesis procedure where the condensation polymerization of alkoxysilane monomers in the presence of the AuNCs and a surfactant produced hybrid MSNs of 49 nm diameter. This method was further developed to prepare 30 nm diameter nanocomposite particles with simultaneous NIR fluorescence and superparamagnetic properties, with a core composed of superparamagnetic manganese (II) ferrite nanoparticles (MnFe2O4) coated with a thin silica layer, and a shell of mesoporous silica decorated with AuNCs. The nanocomposite particles feature NIR-photoluminescence with 0.6% quantum yield and large Stokes shift (290 nm), and superparamagnetic response at 300 K, with a saturation magnetization of 13.4 emu g-1. The conjugation of NIR photoluminescence and superparamagnetic properties in the biocompatible nanocomposite has high potential for application in multimodal bioimaging.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16