Evolution of chromone-like compounds as potential antileishmanial agents, through the 21(st)century

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2020

Autores

Silva, CFM (Autor) Outra; Pinto, DCGA (Autor) Outra; Pedro A Fernandes (Autor) FCUP; Silva, AMS (Autor) Outra

Revista

Título: Expert Opinion on Drug Discovery

Vol. 15

Páginas: 1425-1439

ISSN: 1746-0441

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 7 Citações

Outras Informações

ID Authenticus: P-00S-KYB

DOI: 10.1080/17460441.2020.1801630

Abstract (EN): Introduction Leishmaniasis is one of the most neglected diseases of modern times that mainly affects people from developing countries, with approximately 350 million people considered at risk of developing leishmaniasis. Therefore, the development of novel antileishmanial treatments is becoming the focus of numerous research groups, with the support of the World Health Organization, which hopes to eradicate this disease in the near future. Areas covered This review focuses on the interest of chromones for the development of future treatments against leishmaniasis. In addition to plant-based chromone derivatives, structure-activity relationship studies that aim to identify the optimal structural features of the chromones' antileishmanial activity are also described and discussed. Expert opinion The numerous examples of chromones depicted in this paper, allied with the SAR studies presented herein, suggest that the chromone scaffold is a privileged core for the design and development of novel antileishmanial agents. However, some concerns have been raised concerning the considerable variability observed in the results throughout the scientific bibliography. These inconsistencies may explain the absence of pharmacodynamic and pharmacokinetic studies as well as clinical trials.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15