Putting gluten back on menu - Safety assessment of polyphenol-rich wheat varieties in Celiac Disease

• Tipo: Artigo em Revista Científica Internacional
• Data: 2024

Autores

Dias, R (Autor) Outra; Mottola, I (Autor) Outra; Bellomo, C (Autor) Outra; da Silva, S (Autor) Outra; Milheiro, D (Autor) Outra; Barone, MV (Autor) Outra; Martinek, P (Autor) Outra; Victor de Freitas (Autor) FCUP; Gianfrani, C (Autor) Outra

Revista

Título: EFSA Journal

Vol. 22

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-017-QCX

DOI: 10.2903/j.efsa.2024.e221115

Abstract (EN): This study provides a comprehensive proteomic and metabolomic analysis of novel anthocyanin- and carotenoid-rich wheat varieties to assess their immunogenicity in the context of Celiac Disease. Using (semi)-quantitative mass spectrometry, the research found that gliadin expression and peptide release, particularly those containing immunostimulatory gamma-gliadin epitopes, vary significantly across different wheat varieties. While non-targeted mass spectrometry provided valuable insights, the study acknowledged potential methodological biases, such limitations of ion current intensity as a measure of peptide abundance. Despite promising results, further research is required to determine the safety and efficacy of coloured wheat varieties for Celiac Disease patients, considering the complex interplay of gluten proteins, food processing, digestion and matrix effects. The ongoing studies hold potential for developing nutritionally beneficial wheat alternatives for Celiac Disease management.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9