Kinetic analysis of the ex vivo expansion of human hematopoietic stem/progenitor cells

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

Goncalves, R (Autor) Outra; da Silva, CL (Autor) Outra; Ferreira, BS (Autor) Outra; Lemos, MANDA (Autor) Outra; Lemos, F (Autor) Outra; Almeida Porada, G (Autor) Outra; Cabral, JMS (Autor) Outra

Revista

Título: Biotechnology Letters

Vol. 28

Páginas: 335-340

ISSN: 0141-5492

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 8 Citações

Outras Informações

ID Authenticus: P-004-MVZ

DOI: 10.1007/s10529-005-5932-2

Abstract (EN): The total cell expansion of human umbilical cord blood (CB) and adult bone marrow (BM) CD34(+)-enriched cells cultured in supplemented serum-free media, either over irradiated human feeder layers or in stroma-free systems, were characterized by a simple kinetic model using only two parameters: the specific cell expansion rate, mu, and the death rate constant, k(k). Both CB and BM cells can expand at approximately the same rate (0.21 day(-1)) in this culture system however, cell death depends on the presence of stroma and the environment in which the cells are cultured.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6