Articular Repair/Regeneration in Healthy and Inflammatory Conditions: From Advanced In Vitro to In Vivo Models

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2020

Autores

Teixeira, JH (Autor) Outra; Pereira, CL (Autor) Outra; Almeida, MI (Autor) Outra; Teixeira, GQ (Autor) Outra; Goncalves, RM (Autor) ICBAS; Barbosa, MA (Autor) Outra; Santos, SG (Autor) Outra

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: ADVANCED FUNCTIONAL MATERIALS

Vol. 30

ISSN: 1616-301X

Indexação

ISI Web of Knowledge - 8 Citações

Scopus - 8 Citações

Outras Informações

ID Authenticus: P-00R-WV4

DOI: 10.1002/adfm.201909523

Abstract (EN): The burden of chronic inflammatory diseases of joints and the spine is increasing with population ageing and unhealthy lifestyles. Articular cartilage and intervertebral discs (IVDs) are avascular and aneural tissues with abundant extracellular matrix, low cell density, and reduced regenerative capacity after damage or degeneration. The most advanced in vitro and ex vivo cell-/tissue-/biomaterial-based models and technologies to improve physiological mimicry are discussed, focusing on the impact of inflammation on articular repair/regeneration. In addition, in vivo models, developed to study cartilage and IVD repair/regeneration are addressed. While animal models continue to provide crucial mechanistic and preclinical data, more advanced and robust in vitro/ex vivo cartilage and IVD models, with appropriate extracellular matrix cues and allowing for cellular crosstalk, have seen an exponential growth in the last decade. Due to the complexity of articular microenvironments, adequate in vitro/ex vivo/in vivo models are essential to study the molecular mechanisms underlying articular diseases and develop new therapies for repair/regeneration.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 21