Extracellular vesicles: intelligent delivery strategies for therapeutic applications

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2018

Autores

Pinheiro, A (Autor) Outra; Silva, AM (Autor) Outra; Teixeira, JH (Autor) Outra; Goncalves, RM (Autor) ICBAS; Almeida, MI (Autor) Outra; Barbosa, MA (Autor) Outra; Santos, SG (Autor) Outra

Revista

Título: Journal of Controlled Release

Vol. 289

Páginas: 56-69

ISSN: 0168-3659

Editora: Elsevier

Indexação

ISI Web of Knowledge - 74 Citações

Scopus - 82 Citações

Outras Informações

ID Authenticus: P-00P-NS5

DOI: 10.1016/j.jconrel.2018.09.019

Abstract (EN): Extracellular vesicles (EV), in particular exosomes, have been the object of intense research, due to their potential to mediate intercellular communication, modulating the phenotype of target cells. The natural properties and functions of EV are being exploited as biomarkers for disease diagnosis and prognosis, and as nano-biocarriers for the development of new therapeutic strategies. EV have been particularly examined in the field of cancer, but are also increasingly investigated in other areas, like immune-related diseases and regenerative medicine. In this review, the therapeutic use of EV as drug delivery systems is described, balancing the advantages and drawbacks of different routes for their in vivo administration. Systemic and local delivery of EV are discussed, tackling the persisting difficulties in the assessment of their pharmacokinetics, pharmacodynamics and biodistribution in vivo. Finally, we discuss the future perspectives for incorporating EV into delivery systems and their use for an improved and controlled release of EV in vivo.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14