Synthesis and Antitumor Evaluation of Benzopsoralen Analogues

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Ana M. A. G. Oliveira (Autor) Outra; Ana M. F. Oliveira-Campos (Autor) Outra; Lígia M. Rodrigues (Autor) Outra; M. Manuela M. Raposo (Autor) Outra; Antonio E. H. Machado (Autor) Outra; M. São José Nascimento (Autor) FFUP; N. Nazareth (Autor) Outra; Madalena Pinto (Autor) FFUP

Revista

Título: Chemistry and Biodiversity

Vol. 4 Nº 5

Páginas: 980-990

ISSN: 1612-1872

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 7 Citações

ISI Web of Science

Scopus - 8 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-004-CQ2

Resumo (PT): The synthesis of five new tetracyclic benzopsoralen analogues, compounds 2–6, with 9H-xanthen-9-one or 9H-carbazole frameworks, is described. Their inhibitory effects on the growth of three human tumor cell lines (MCF-7, SF-268, and NCI-460) were evaluated, and discussed in terms of structure–activity relationship, taking into account both geometric and electronic features. Generally, the angular compounds showed significant biological activities, but the arrangement of functional groups also contributed to the overall activity. <br> <br> Keywords:Antitumor activity;Tumor growth inhibition;Benzopsoralen;Structure–activity relationship (SAR);Cytotoxic activity;Carbazoles;Xanthones <br> <a target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790089/abstract"> Texto integral </a> <br> <br>

Abstract (EN): The synthesis of five new tetracyclic benzopsoralen analogues, compounds 2–6, with 9H-xanthen-9-one or 9H-carbazole frameworks, is described. Their inhibitory effects on the growth of three human tumor cell lines (MCF-7, SF-268, and NCI-460) were evaluated, and discussed in terms of structure–activity relationship, taking into account both geometric and electronic features. Generally, the angular compounds showed significant biological activities, but the arrangement of functional groups also contributed to the overall activity. <br> <br> Keywords:Antitumor activity;Tumor growth inhibition;Benzopsoralen;Structure–activity relationship (SAR);Cytotoxic activity;Carbazoles;Xanthones <br> <a target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790089/abstract"> Full text </a> <br> <br>

Idioma: Inglês

Tipo (Avaliação Docente): Científica