A post-mortem study of the anatomical region differences and age-related changes on Ca and Mg levels in the human brain

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Helder Correia (Autor) Outra; Patricia Ramos (Autor) Outra; Agostinho Santos (Autor) Outra; Nair Rosas Pinto (Autor) Outra; Ricardo Mendes (Autor) Outra; Teresa Magalhaes (Autor) Outra; Agostinho Almeida (Autor) FFUP

Revista

Título: Microchemical Journal

Vol. 113

ISSN: 0026-265X

Editora: Elsevier

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 5 Citações

Current Contents

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina > Investigação do cérebro ; Ciências da Saúde > Neurociências

Outras Informações

ID Authenticus: P-008-JEE

Abstract (EN): Calcium and magnesium levels in 14 different areas of the human brain [frontal cortex, superior and middle temporal gyri, caudate nucleus, putamen, globus pallidus, cingulated gyrus, hippocampus, inferior parietal lobule, visual cortex of the occipital lobe, midbrain, pons-locus coeruleus, medulla and cerebellum-dentate nucleus] of adult individuals (n = 42; 71 +/- 12, range: 50-103 years old) without a known history of neurodegenerative, neurological or psychiatric disorder were studied. Considering the mean values for the 14 regions, Mg was present at ca. 2.3-fold higher levels than Ca (mean +/-: 527 +/- 34 mu g/g versus 226 +/- 53 mu g/g). Calcium distribution within the brain showed to be quite heterogeneous: highest levels were found in the occipital (306 +/- 156 mu g/g) and frontal cortex (287 +/- 78 ug/g), while lowest levels were found in the medulla (186 +/- 70 mu g/g) and cerebellum (145 +/- 42 mu g/g). Higher Ca levels were found in women than in men (248 +/- 59 mu g/g versus 213 +/- 46 mu g/g; p < 0.05). A tendency for Ca levels to increase with age in all studied brain regions and in both genders was also observed. On the contrary, Mg presented a highly homogeneous distribution and seems to remain quite unchanged irrespective of aging. (C) 2013 Elsevier B.V. All rights reserved.

Idioma: Inglês

Tipo (Avaliação Docente): Científica