Synthesis and Antimalarial Properties of New Chloro-9H-xanthones with an Aminoalkyl Side Chain

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

César Portela (Autor) Outra; Carlos M. M. Afonso (Autor) FFUP; Madalena M. M. Pinto (Autor) FFUP; Dinora Lopes (Autor) Outra; Fátima Nogueira (Autor) Outra; Virgílio do Rosário (Autor) Outra

Revista

Título: Chemistry and Biodiversity

Vol. 4 Nº 7

Páginas: 1508-1519

ISSN: 1612-1872

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 20 Citações

ISI Web of Science

Scopus - 21 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-004-CQ3

Resumo (PT): The synthesis and antimalarial properties of twelve new chlorinated 9H-xanthones, carrying a [2-(diethylamino)ethyl]amino group in position 1, are reported. All compounds were found to be active towards the chloroquine-susceptible and chloroquine-resistant strains 3D7 and Dd2, resp., of the protozoa parasite Plasmodium falciparum. Especially one compound, 6-chloro-1-{[2-(diethylamino)ethyl]amino}-9H-xanthen-9-one (1k), was found to exhibit significant in vitro activity (IC50=3.9 μM) towards the resistant Dd2 strain <br> <br> Keywords:Antimalaria activity;Plasmodium falciparum;Aminoalkylchloroxanthones;9H-Xanthen-9-ones, chloro- <br> <a target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790130/abstract"> Texto integral</a> <br> <br>

Abstract (EN): The synthesis and antimalarial properties of twelve new chlorinated 9H-xanthones, carrying a [2-(diethylamino)ethyl]amino group in position 1, are reported. All compounds were found to be active towards the chloroquine-susceptible and chloroquine-resistant strains 3D7 and Dd2, resp., of the protozoa parasite Plasmodium falciparum. Especially one compound, 6-chloro-1-{[2-(diethylamino)ethyl]amino}-9H-xanthen-9-one (1k), was found to exhibit significant in vitro activity (IC50=3.9 μM) towards the resistant Dd2 strain <br> <br> Keywords:Antimalaria activity;Plasmodium falciparum;Aminoalkylchloroxanthones;9H-Xanthen-9-ones, chloro- <br> <a target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790130/abstract">Full text</a> <br> <br>

Idioma: Inglês

Tipo (Avaliação Docente): Científica