Assessing the antioxidative properties and chemical composition of Linaria vulgaris infusion

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Vrchovska, V (Autor) Outra; Spilkova, J (Autor) Outra; Valentao, P (Autor) FFUP; Sousa, C (Autor) REIT; Andrade, PB (Autor) FFUP; Seabra, RM (Autor) Outra

Revista

Título: Natural Product Research

Vol. 22 Nº 17

Páginas: 735-746

ISSN: 1478-6419

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 7 Citações

ISI Web of Science

Scopus - 11 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-004-476

DOI: 10.1080/14786410601132360

Resumo (PT): The ability of Linaria vulgaris (Scrophulariaceae) infusion to act as a scavenger of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, reactive oxygen species (superoxide radical, hydroxyl radical, hypochlorous acid (HOCl)) and nitric oxide was investigated. The obtained data indicate that the infusion has a good scavenging activity against superoxide radical and is a very potent nitric oxide and DPPH scavenger. In hydroxyl radical assay a pro-oxidant capacity was noticed, especially for concentrations higher than 31.25 µg mL-1. No effect was found against HOCl. A phytochemical study of this extract was also performed. The HPLC/UV analysis allowed the identification and quantification of eight organic acids (oxalic, aconitic, citric, ketoglutaric, ascorbic, malic, shikimic and fumaric acids). The phenolic composition of the lyophilised infusion was also determined by HPLC/DAD and four compounds were quantified, but, despite its high content, only linarin was managed to be identified. <br> <br> Keywords: Linaria vulgaris; DPPH; reactive oxygen species; nitric oxide; phenolic compounds; organic acids <br> <a target="_blank" href="http://www.informaworld.com/smpp/content~db=all~content=a793969747"> Texto integral</a> <br> <br>

Abstract (EN): The ability of Linaria vulgaris (Scrophulariaceae) infusion to act as a scavenger of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, reactive oxygen species (superoxide radical, hydroxyl radical, hypochlorous acid (HOCl)) and nitric oxide was investigated. The obtained data indicate that the infusion has a good scavenging activity against superoxide radical and is a very potent nitric oxide and DPPH scavenger. In hydroxyl radical assay a pro-oxidant capacity was noticed, especially for concentrations higher than 31.25 g mL(-1). No effect was found against HOCl. A phytochemical study of this extract was also performed. The HPLC/UV analysis allowed the identification and quantification of eight organic acids (oxalic, aconitic, citric, ketoglutaric, ascorbic, malic, shikimic and fumaric acids). The phenolic composition of the lyophilised infusion was also determined by HPLC/DAD and four compounds were quantified, but, despite its high content, only linarin was managed to be identified.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12