Sequential injection lab-on-valve procedure for the determination of amantadine using potentiometric methods

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Amorim, CG (Autor) Outra; Araujo, AN (Autor) FFUP; Montenegro, MCBSM (Autor) FFUP; Silva, VL (Autor) Outra

Revista

Título: Electroanalysis

Vol. 19 Nº 21

Páginas: 2227-2233

ISSN: 1040-0397

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 20 Citações

ISI Web of Science

Scopus - 21 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-004-6F9

DOI: 10.1002/elan.200703973

Resumo (PT): Amantadine potentiometric detectors were developed, evaluated and incorporated in a SIA-LOV manifold in order to accomplish the control of pharmaceutical formulations and urine. The electrodes incorporate -cyclodextrin as ionophore, dibutyl phthalate or 2-fluorophenyl 2-nitrophenyl ether as plasticizers and potassium tetrakis[3,5-bis-(trifluoromethyl)phenyl]borate (KTFPB) as cationic additive. The slope increased from 61.2 to 63.8 mV decade-1 and the practical limit of detection from 2.6×10-6 mol L-1 to 2.5×10-5 mol L-1 when the plasticizer was changed from 2-fluorophenyl 2-nitrophenyl ether to dibutyl phthalate. When incorporated in the flow-manifold the membranes composed by dibutyl phthalate or with 2-fluorophenyl 2-nitrophenyl ether presented slopes and a practical limit of detection of 69.8 mV decade-1 and 1.5×10-4 mol L-1 or 73.7 mV decade-1 and 5.4×10-5 mol L-1, respectively. The electrode presented stable responses for over a year, and were highly selective concerning the representative species of the two sample matrices assayed as interferents. Comparison of obtained results with those provided by reference methods and recovery assays, revealed adequate accuracy for control assays. <br> <br> Keywords Lab-on-valve • Ion selective electrodes • Potentiometry • Amantadine • Cyclodextrin <br> <a target="_blank" href="http://www3.interscience.wiley.com/journal/116324534/abstract"> Texto integral</a> <br> <br>

Abstract (EN): Amantadine potentiometric detectors were developed, evaluated and incorporated in a SIA-LOV manifold in order to accomplish the control of pharmaceutical formulations and urine. The electrodes incorporate a-cyclodextrin as ionophore, dibutyl phthalate or 2-fluorophenyl 2-nitrophenyl ether as plasticizers and potassium tetrakis[3,5-bis-(trifluoromethyl)phenyl]borate (KTFPB) as cationic additive. The slope increased from 61.2 to 63.8 mV decade(-1) and the practical limit of detection from 2.6 x 10(-6) mol L-1 to 2.5 x 10(-5) mol L-1 when the plasticizer was changed from 2-fluorophenyl 2-nitrophenyl ether to dibutyl phthalate. When incorporated in the flow-manifold the membranes composed by dibutyl phthalate or with 2-fluorophenyl 2-nitrophenyl ether presented slopes and a practical limit of detection of 69.8 mV decade(-1) and 1.5 x 10(-4) mol L-1 or 73.7 mV decade(-1) and 5.4 x 10(-5) mol L-1, respectively. The electrode presented stable responses for over a year, and were highly selective concerning the representative species of the two sample matrices assayed as interferents. Comparison of obtained results with those provided by reference methods and recovery assays, revealed adequate accuracy for control assays.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7