Lipid Profile in Portuguese Obese Children and Adolescents Interaction of Apolipoprotein E Polymorphism With Adiponectin Levels

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Henrique Nascimento (Autor) Outra; Leticia Silva (Autor) Outra; Pedro Lourenco (Autor) Outra; Radka Weinfurterova (Autor) Outra; Elisabeth Castro (Autor) Outra; Carla Rego (Autor) FMUP; Helena Ferreira (Autor) Outra; Antonio Guerra (Autor) FMUP; Alexandre Quintanilha (Autor) ICBAS; Alice Santos Silva (Autor) FFUP; Luis Belo (Autor) FFUP

Revista

Título: Archives of Pediatrics & Adolescent Medicine

Vol. 163 Nº 4

Páginas: 1030-1036

ISSN: 1072-4710

Indexação

ISI Web of Knowledge - 13 Citações

ISI Web of Science

Scopus - 16 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-003-EG4

DOI: 10.1001/archpediatrics.2009.190

Resumo (PT): Objective To evaluate how the lipid profile associates with apolipoprotein (apo) E gene polymorphism, plasma adiponectin level, and body mass index (BMI) z score in Portuguese youth. Design Transversal cohort study. Setting Hospital de São João and Hospital de Crianças Maria Pia, Porto, Portugal, between May 2006 and March 2007. Participants One hundred thirty-eight obese children and adolescents (62 boys; mean age, 10.8 years [range, 4-16 years]). Participants were grouped according to (1) apo E polymorphism: presence of the apo E alleles 2 or 4 in E2 (n = 11) and E4 (n = 31) carriers, respectively, or as E3/E3 (n = 94) (carriers of E2/E4 [n = 2] were excluded from apo E analysis because they carry both alleles) and (2) BMI z score: group 1, BMI z score less than 2 (n = 31); group 2, BMI z score of 2 or more and less than 2.5 (n = 65); and group 3, BMI z score of 2.5 or more (n = 42). Main Outcome Measures Lipid variable comparisons between apo E polymorphism and BMI z score groups and influence of BMI z score and adiponectin level, adjusted for apo E polymorphism, on total cholesterol to high-density lipoprotein cholesterol and apo A-I to apo B ratios. Results E4 carriers presented with a worse lipid profile when compared with E2 and E3/E3 carriers. There was also a clear risk of worsening for the group with the highest BMI z score. Apolipoprotein E polymorphism, BMI z score, and adiponectin level were significantly associated with total cholesterol to high-density lipoprotein cholesterol (standardized β coefficient = 0.283, 0.354, and –0.292, respectively; P < .001 for all) and apo A-I to apo B (standardized β coefficient = –0.372, –0.284, and 0.327, respectively; P < .001 for all) ratios. Conclusion Our data suggest a more atherogenic lipid profile for some apo E genotypes and for increasing BMI z score, whereas adiponectin level seems to play a protective role. <br> <br>

Abstract (EN): Objective: To evaluate how the lipid profile associates with apolipoprotein (apo) E gene polymorphism, plasma adiponectin level, and body mass index (BMI) z score in Portuguese youth. Design: Transversal cohort study. Setting: Hospital de Sao Joao and Hospital de Criancas Maria Pia, Porto, Portugal, between May 2006 and March 2007. Participants: One hundred thirty-eight obese children and adolescents (62 boys; mean age, 10.8 years [range, 4-16 years]). Participants were grouped according to (1) apo E polymorphism: presence of the apo E alleles 2 or 4 in E2 (n = 11) and E4 (n = 31) carriers, respectively, or as E3/E3 (n = 94) (carriers of E2/E4 [n = 2] were excluded from apo E analysis because they carry both alleles) and (2) BMI z score: group 1, BMI z score less than 2 (n = 31); group 2, BMI z score of 2 or more and less than 2.5 (n = 65); and group 3, BMI z score of 2.5 or more (n = 42). Main Outcome Measures: Lipid variable comparisons between apo E polymorphism and BMI z score groups and influence of BMI z score and adiponectin level, adjusted for apo E polymorphism, on total cholesterol to high-density lipoprotein cholesterol and apo A-I to apo B ratios. Results: E4 carriers presented with a worse lipid profile when compared with E2 and E3/E3 carriers. There was also a clear risk of worsening for the group with the highest BMI z score. Apolipoprotein E polymorphism, BMI z score, and adiponectin level were significantly associated with total cholesterol to high-density lipoprotein cholesterol (standardized beta coefficient = 0.283, 0.354, and -0.292, respectively; P < .001 for all) and apo A-I to apo B (standardized beta coefficient = -0.372, -0.284, and 0.327, respectively; P < .001 for all) ratios. Conclusion: Our data suggest a more atherogenic lipid profile for some apo E genotypes and for increasing BMI z score, whereas adiponectin level seems to play a protective role.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7