Lack of complete biochemical response in autoimmune hepatitis leads to adverse outcome: First report of the IAIHG retrospective registry

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Slooter, CD (Autor) Outra; van den Brand, FF (Autor) Outra; Lleo, A (Autor) Outra; Colapietro, F (Autor) Outra; Lenzi, M (Autor) Outra; Muratori, P (Autor) Outra; Kerkar, N (Autor) Outra; Dalekos, GN (Autor) Outra; Zachou, K (Autor) Outra; Lucena, MI (Autor) Outra; Robles-Díaz, M (Autor) Outra; Di Zeo-Sánchez, DE (Autor) Outra; Andrade, RJ (Autor) Outra; Montano-Loza, AJ (Autor) Outra; Lytvyak, E (Autor) Outra; Lissenberg-Witte, BI (Autor) Outra; Maisonneuve, P (Autor) Outra; Bouma, G (Autor) Outra; Macedo G (Autor) FMUP; Liberal, R (Autor) Outra; de Boer, YS (Autor) Outra

Revista

Título: Hepatology

Vol. 79

Páginas: 538-550

ISSN: 0270-9139

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 14 Citações

Outras Informações

ID Authenticus: P-00Z-WDX

DOI: 10.1097/hep.0000000000000589

Abstract (EN): Background and Aims: The International Autoimmune Hepatitis Group retrospective registry (IAIHG-RR) is a web-based platform with subjects enrolled with a clinical diagnosis of autoimmune hepatitis (AIH). As prognostic factor studies with enough power are scarce, this study aimed to ascertain data quality and identify prognostic factors in the IAIHG-RR cohort. Methods: This retrospective, observational, multicenter study included all patients with a clinical diagnosis of AIH from the IAIHG-RR. The quality assessment consisted of external validation of completeness and consistency for 29 predefined variables. Cox regression was used to identify risk factors for liver-related death and liver transplantation (LT). Results: This analysis included 2559 patients across 7 countries. In 1700 patients, follow-up was available, with a completeness of individual data of 90% (range: 30-100). During a median follow-up period of 10 (range: 0-49) years, there were 229 deaths, of which 116 were liver-related, and 143 patients underwent LT. Non-White ethnicity (HR 4.1 95% CI: 2.3-7.1), cirrhosis (HR 3.5 95% CI: 2.3-5.5), variant syndrome with primary sclerosing cholangitis (PSC) (HR 3.1 95% CI: 1.6-6.2), and lack of complete biochemical response within 6 months (HR 5.7 95% CI: 3.4-9.6) were independent prognostic factors. Conclusions: The IAIHG-RR represents the world's largest AIH cohort with moderate-to-good data quality and a relevant number of liver-related events. The registry is a suitable platform for patient selection in future studies. Lack of complete biochemical response to treatment, non-White ethnicity, cirrhosis, and PSC-AIH were associated with liver-related death and LT.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13