Risk of Residual Neoplasia after a Local-Risk Resection of Colorectal Lesions by Endoscopic Submucosal Dissection: A Multinational Study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

João Santos-Antunes (Autor) FMUP; Pioche, M (Autor) Outra; Ramos Zabala, F (Autor) Outra; Cecinato, P (Autor) Outra; Gallego, F (Autor) Outra; Barreiro, P (Autor) Outra; Mascarenhas, A (Autor) Outra; Sferrazza, S (Autor) Outra; Berr, F (Autor) Outra; Wagner, A (Autor) Outra; Lemmers, A (Autor) Outra; Ferreira, MF (Autor) Outra; Albeniz, E (Autor) Outra; Uchima, H (Autor) Outra; Kuttner Magalhaes, R (Autor) Outra; Fernandes, C (Autor) Outra; Morais, R (Autor) Outra; Gupta, S (Autor) Outra; Martinho Dias, D (Autor) Outra; Faria Ramos, I (Autor) Outra; Marques, M (Autor) Outra; Bourke, MJ (Autor) Outra; Macedo G (Autor) FMUP

Revista

Título: Journal of Clinical Medicine

Vol. 36

Página Final: 5356

ISSN: 2077-0383

Editora: MDPI

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-00Y-Z34

DOI: 10.3390/jcm12165356

Abstract (EN): Endoscopic submucosal dissection (ESD) in colorectal lesions is demanding, and a significant rate of non-curative procedures is expected. We aimed to assess the rate of residual lesion after a piecemeal ESD resection, or after an en bloc resection but with positive horizontal margins (local-risk resection-LocRR), for colorectal benign neoplasia. A retrospective multicenter analysis of consecutive colorectal ESDs was performed. Patients with LocRR ESDs for the treatment of benign colorectal lesions with at least one follow-up endoscopy were included. A cohort of en bloc resected lesions, with negative margins, was used as the control. A total of 2255 colorectal ESDs were reviewed; 352 of the ESDs were non-curative. Among them, 209 were LocRR: 133 high-grade dysplasia and 76 low-grade dysplasia. Ten cases were excluded due to missing data. A total of 146 consecutive curative resections were retrieved for comparison. Compared to the curative group, LocRRs were observed in lengthier procedures, with larger lesions, and in non-granular LSTs. Recurrence was higher in the LocRR group (16/199, 8% vs. 1/146, 0.7%; p = 0.002). However, statistical significance was lost when considering only en bloc resections with positive horizontal margins (p = 0.068). In conclusion, a higher rate of residual lesion was found after a piecemeal ESD resection, but not after an en bloc resection with positive horizontal margins.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9