Fractal protein structure revisited: Topological, kinetic and thermodynamic relationships

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Tejera, E (Autor) Outra; Machado, A (Autor) Outra; Rebelo, I (Autor) FFUP; Nieto Villar, J (Autor) Outra

Revista

Título: Physica A: Statistical Mechanics and its Applications

Vol. 388

Páginas: 4600-4608

ISSN: 0378-4371

Editora: Elsevier

Indexação

ISI Web of Knowledge - 14 Citações

ISI Web of Science

Scopus - 15 Citações

Classificação Científica

CORDIS: Ciências da Saúde

FOS: Ciências exactas e naturais > Física

Outras Informações

ID Authenticus: P-003-EVW

DOI: 10.1016/j.physa.2009.07.015

Resumo (PT): The present work explored the definitions and calculations of fractal dimensions in protein structures and the corresponding relationships with the protein class, secondary structure contents, fold type as well as kinetic and thermodynamic parameters like the folding and unfolding rate, the folding–unfolding free energy and others. The results showed a positive correlation of some fractal exponents with the kinetic and thermodynamic variables even considering the effect of the protein length. On the other hand the influences of secondary structures types, especially the turn conformation are significant as well as the fractal exponent profiles according to class and fold types. <br> <br> Keywords: Fractal dimension; Protein length; Thermodynamic; Folding rate; Spectral dimension; Contact map <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TVG-4WSRF2K-7&_user=2460038&_coverDate=11%2F01%2F2009&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=e903b2cef67cc3e1800f3eba14197bae "> Texto integral </a> <br> <br>

Abstract (EN): The present work explored the definitions and calculations of fractal dimensions in protein structures and the corresponding relationships with the protein class, secondary structure contents, fold type as well as kinetic and thermodynamic parameters like the folding and unfolding rate, the folding-unfolding free energy and others. The results showed a positive correlation of some fractal exponents with the kinetic and thermodynamic variables even considering the effect of the protein length. On the other hand the influences of secondary structures types, especially the turn conformation are significant as well as the fractal exponent profiles according to class and fold types.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9