Fetal lipoprotein changes in pre-eclampsia

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Cristina Catarino (Autor) FFUP; Irene Rebelo (Autor) FFUP; Luis Belo (Autor) FFUP; Petronila Rocha Pereira (Autor) Outra; Susana Rocha (Autor) FFUP; Elisabeth Bayer Castro (Autor) Outra; Belmiro Patricio (Autor) Outra; Alexandre Quintanilha (Autor) ICBAS; Alice Santos Silva (Autor) FFUP

Revista

Título: Acta Obstetricia et Gynecologica Scandinavica

Vol. 87 Nº 6

Páginas: 628-634

ISSN: 0001-6349

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 25 Citações

ISI Web of Science

Scopus - 29 Citações

Classificação Científica

CORDIS: Ciências da Saúde

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-004-24K

DOI: 10.1080/00016340802085318

Resumo (PT): Objective. To evaluate the impact of maternal lipid changes upon the fetus in pre-eclampsia (PE) by evaluating lipid profile simultaneously in maternal and umbilical cord blood (UCB). Design. Case-control study performed on healthy and pre-eclamptic pregnant women and their neonates. Setting. The Department of Obstetrics and Gynecology, Hospital S. Joao and Faculty of Pharmacy, Porto, Portugal. Samples. Forty-two healthy pregnancies and 46 pregnancies complicated with PE. Methods. Total cholesterol (TChol), HDL-cholesterol (HDLc), LDL-cholesterol (LDLc) and triglycerides (TG) levels were determined using enzymatic methods. Apolipoprotein (apo) A-I, apoB and lipoprotein (a) [Lp(a)] values were measured by immunoturbidimetry. Main outcome measures. Fetal and maternal plasma levels of TChol, HDLc, LDLc, TG, apoA-I, apoB and Lp(a). Results. Pre-eclamptic women presented significantly higher values for TChol, LDLc, HDLc, TG, apoA-I and apoB compared to normal pregnant women. In the UCB from pre-eclamptic pregnancies, we observed significantly lower values for HDLc and apoA-I, and significantly higher TG concentrations and LDLc/HDLc ratio when compared to normal cases. A positive correlation was observed between maternal TG levels and proteinuria, a marker of PE severity (r =0.40, p <0.01). Conclusions. Our data suggest that pre-eclamptic pregnancy is associated with an enhanced hyperlipidemia, which seems to have a negative impact on fetal lipid profile, as reflected by a higher atherogenic LDLc/HDLc ratio and higher TG levels. These children, born of women with PE, may deserve a closer clinical follow-up later in life. <br> <br> Keywords: lipids lipoproteins pre-eclampsia Pregnancy umbilical cord blood <br> <a target="_blank" href="http://web.ebscohost.com/ehost/detail?vid=5&hid=5&sid=4554f1b8-b9be-4880-b8c7-4aa88f11ebcc%40sessionmgr2&bdata=JnNpdGU9ZWhvc3QtbGl2ZSZzY29wZT1zaXRl#db=a9h&AN=32707122#db=a9h&AN=32707122#db=a9h&AN=32707122#db=a9h&AN=32707122#db=a9h&AN=32707122#db=a9h&AN=32707122#db=a9h&AN=32707122#db=a9h&AN=32707122#db=a9h&AN=32707122#db=a9h&AN=32707122#db=a9h&AN=32707122"> Texto integral </a> <br> <br>

Abstract (EN): Objective. To evaluate the impact of maternal lipid changes upon the fetus in pre-eclampsia (PE) by evaluating lipid profile simultaneously in maternal and umbilical cord blood (UCB). Design. Case-control study performed on healthy and pre-eclamptic pregnant women and their neonates. Setting. The Department of Obstetrics and Gynecology, Hospital S. Joao and Faculty of Pharmacy, Porto, Portugal. Samples. Forty-two healthy pregnancies and 46 pregnancies complicated with PE. Methods. Total cholesterol (TChol), HDL-cholesterol (HDLc), LDL-cholesterol (LDLc) and triglycerides (TG) levels were determined using enzymatic methods. Apolipoprotein (apo) A-I, apoB and lipoprotein (a) [Lp(a)] values were measured by immunoturbidimetry. Main outcome measures. Fetal and maternal plasma levels of TChol, HDLc, LDLc, TG, apoA-I, apoB and Lp(a). Results. Pre-eclamptic women presented significantly higher values for TChol, LDLc, HDLc, TG, apoA-I and apoB compared to normal pregnant women. In the UCB from pre-eclamptic pregnancies, we observed significantly lower values for HDLc and apoA-I, and significantly higher TG concentrations and LDLc/HDLc ratio when compared to normal cases. A positive correlation was observed between maternal TG levels and proteinuria, a marker of PE severity (r = 0.40, p < 0.01). Conclusions. Our data suggest that pre-eclamptic pregnancy is associated with an enhanced hyperlipidemia, which seems to have a negative impact on fetal lipid profile, as reflected by a higher atherogenic LDLc/HDLc ratio and higher TG levels. These children, born of women with PE, may deserve a closer clinical follow-up later in life.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7