Chemical composition and biological screening of Capsella bursa-pastoris

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Clara Grosso (Autor) Outra; Juliana Vinholes (Autor) Outra; Luis R Silva (Autor) Outra; de Pinho, PG (Autor) FFUP; Rui F Goncalves (Autor) Outra; Patricia Valentao (Autor) FFUP; Anna K Jager (Autor) Outra; Paula B Andrade (Autor) FFUP

Revista

Título: Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Vol. 21 Nº 4

Páginas: 635-644

ISSN: 0102-695X

Indexação

ISI Proceedings

ISI Web of Knowledge - 34 Citações

Scopus - 50 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde > Ciências farmacológicas > Farmacognosia

Outras Informações

ID Authenticus: P-002-PWX

DOI: 10.1590/s0102-695x2011005000107

Resumo (PT): Capsella bursa-pastoris (L.) Medik. (Brassicaceae) is a wild herb with high nutritional value that can be eaten raw or cooked. A metabolomic study was performed with different extracts of its aerial parts that were tested concerning their antiradical, acetylcholinesterase inhibitory and antibacterial activities. Phenolic compounds were identified and quantified by HPLC-DAD, organic acids and amino acids were determined by HPLC-UV, while free fatty acids and sterols were analysed by GC-ITMS. The vegetal material was rich in kaempferol-3-O-rutinoside (mean value 2247.09 mg/kg of dry plant), quinic acid (95628.00 mg/kg of dry plant), arginine (mean value of 1.18 mg/kg of dry plant), palmitic acid (284.48 mg/kg) and β-sitosterol (28%). The extracts presented a concentration-dependent antiradical activity (against DPPH•, O2 •- and LOO•), being most effective against •NO (EC25 0.20 μg/mL). In addition, the extracts were also acetylcholinesterase inhibitors and antibacterial active, revealing that, besides the plant’s good nutritional value, it presents important biological properties as well. <br> <br> <a target="_blank" href="http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000400012&lng=pt&nrm=iso&tlng=en"> Texto integral </a> <br> <br>

Abstract (EN): Capsella bursa-pastoris (L.) Medik. (Brassicaceae) is a wild herb with high nutritional value that can be eaten raw or cooked. A metabolomic study was performed with different extracts of its aerial parts that were tested concerning their antiradical, acetylcholinesterase inhibitory and antibacterial activities. Phenolic compounds were identified and quantified by HPLC-DAD, organic acids and amino acids were determined by HPLC-UV, while free fatty acids and sterols were analysed by GC-ITMS. The vegetal material was rich in kaempferol-3-O-rutinoside (mean value 2247.09 mg/kg of dry plant), quinic acid (95628.00 mg/kg of dry plant), arginine (mean value of 1.18 mg/kg of dry plant), palmitic acid (284.48 mg/kg) and beta-sitosterol (28%). The extracts presented a concentration-dependent antiradical activity (against DPPH center dot, O-2(center dot-) and LOO center dot), being most effective against (NO)-N-center dot (EC25 0.20 mu g/mL). In addition, the extracts were also acetylcholinesterase inhibitors and antibacterial active, revealing that, besides the plant's good nutritional value, it presents important biological properties as well.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10