Characterization of Polymeric Solutions as Injectable Vehicles for Hydroxyapatite Microspheres

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Serafim M Oliveira (Autor) Outra; Isabel F Almeida (Autor) FFUP; Paulo C Costa (Autor) FFUP; Cristina C Barrias (Autor) Outra; Rosa R P Pena Ferreira (Autor) Outra; Fernanda F Bahia (Autor) Outra; Mario A Barbosa (Autor) FEUP

Revista

Título: AAPS PharmSciTech

Vol. 11 Nº 2

Páginas: 852-858

ISSN: 1530-9932

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 19 Citações

Scopus - 22 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-003-5SE

DOI: 10.1208/s12249-010-9447-3

Abstract (EN): A polymeric solution and a reinforcement phase can work as an injectable material to fill up bone defects. However, the properties of the solution should be suitable to enable the transport of that extra phase. Additionally, the use of biocompatible materials is a requirement for tissue regeneration. Thus, we intended to optimize a biocompatible polymeric solution able to carry hydroxyapatite microspheres into bone defects using an orthopedic injectable device. To achieve that goal, polymers usually regarded as biocompatible were selected, namely sodium carboxymethylcellulose, hydroxypropylmethylcellulose, and Na-alginate (ALG). The rheological properties of the polymeric solutions at different concentrations were assessed by viscosimetry before and after moist heat sterilization. In order to correlate rheological properties with injectability, solutions were tested using an orthopedic device applied for minimal invasive surgeries. Among the three polymers, ALG solutions presented the most suitable properties for our goal and a non-sterile ALG 6% solution was successfully used to perform preliminary injection tests of hydroxyapatite microspheres. Sterile ALG 7.25% solution was found to closely match non-sterile ALG 6% properties and it was selected as the optimal vehicle. Finally, sterile ALG 7.25% physical stability was studied at different temperatures over a 3-month period. It was observed that its rheological properties presented minor changes when stored at 25A degrees C or at 4A degrees C.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7