Haemostatic factors in women with history of Preeclampsia

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Ana Portelinha (Autor) Outra; Ana Sofia Cerdeira (Autor) Outra; Luis Belo (Autor) FFUP; Jorge Braga (Autor) Outra; Eduardo Tejera (Autor) Outra; Ana Pinto (Autor) Outra; Fatima Pinto (Autor) Outra; Maria Jose Areias (Autor) Outra; Belmiro Patricio (Autor) Outra; Irene Rebelo (Autor) FFUP

Revista

Título: Thrombosis Research

Vol. 124 Nº 1

Páginas: 52-56

ISSN: 0049-3848

Editora: Elsevier

Indexação

ISI Web of Knowledge - 10 Citações

Scopus - 11 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-003-KNX

DOI: 10.1016/j.thromres.2008.10.005

Resumo (PT): Objective: Evaluation of haemostatic parameters - Plasma tissue plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1) and fibrin fragment D-dimer several years after the end of pregnancy to investigate if they are modified in women with history of preeclampsia (PE). Study design: 65 healthy women with history of PE and 54 control women with previous normal pregnancy were enrolled in this study. Groups were matched for age, time period since delivery, smoking status and alcohol consumption. t-PA, PAI-1 and fibrin fragment D-dimer antigen levels were quantified using standards commercial ELISA methods. Plasma fibrinogen was measured using automated capillary zone electrophoresis. Results: Systolic and diastolic blood pressures were higher in women with history of PE. Levels of t-PA, PAI-1 and fibrinogen were similar between groups as well as the t-PA/PAI-1 ratio. A significant increase in D-dimer levels was observed in women with history of PE. Conclusion: The increase in D-dimer level suggests an abnormal haemostatic potential namely increased intravascular coagulation. This, together with the increased blood pressure, can reflect a tendency for an increased risk of cardiovascular/thrombotic events later in life. <br> <br> Keywords: Cardiovascular disease; D-dimer; PAI-1; Preeclampsia; t-PA, fibrinogen, haemostatic factors <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1C-4V28STN-1&_user=2460038&_coverDate=05%2F31%2F2009&_rdoc=12&_fmt=high&_orig=browse&_srch=doc-info(%23toc%234887%232009%23998759998%231063060%23FLA%23display%23Volume)&_cdi=4887&_sort=d&_docanchor=&_ct=29&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=cc2a79b1b6054fe97789161aa3f1ad48"> Texto integral</a> <br> <br>

Abstract (EN): Objective: Evaluation of haemostatic parameters - Plasma tissue plasminogen activator (t-PA), plasminogen activator inhibitor type I (PAI-1) and fibrin fragment D-dimer several years after the end of pregnancy to investigate if they are modified in women with history of preeclampsia (PE). Study design: 65 healthy women with history of PE and 54 control women with previous normal pregnancy were enrolled in this study. Groups were matched for age, time period since delivery, smoking status and alcohol consumption. t-PA, PAI-1 and fibrin fragment D-dimer antigen levels were quantified using standards commercial ELISA methods. Plasma fibrinogen was measured using automated capillary zone electrophoresis. Results: Systolic and diastolic blood pressures were higher in women with history of PE. Levels of t-PA, PAI-1 and fibrinogen were similar between groups as well as the t-PA/PAI-1 ratio. A significant increase in D-dimer levels was observed in women with history of PE. Conclusion: The increase in D-dimer level suggests an abnormal haemostatic potential namely increased intravascular coagulation. This, together with the increased blood pressure, can reflect a tendency for an increased risk of cardiovascular/thrombotic events later in life.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5