Relationship between maternal and cord blood hemostatic disturbances in preeclamptic pregnancies

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Cristina Catarino (Autor) FFUP; Irene Rebelo (Autor) FFUP; Luis Belo (Autor) FFUP; Susana Rocha (Autor) FFUP; Elisabeth B Castro (Autor) Outra; Belmiro Patricio (Autor) Outra; Alexandre Quintanilha (Autor) ICBAS; Alice Santos Silva (Autor) FFUP

Revista

Título: Thrombosis Research

Vol. 123 Nº 2

Páginas: 219-224

ISSN: 0049-3848

Editora: Elsevier

Indexação

ISI Web of Knowledge - 12 Citações

ISI Web of Science

Scopus - 18 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-004-4Y7

DOI: 10.1016/j.thromres.2008.02.007

Resumo (PT): Endothelial cell activation or damage is believed to play a key role in preeclampsia (PE) and may underlie the hemostatic changes observed in this syndrome. The aim of this study was to evaluate a relationship between maternal and cord blood hemostatic disturbances in preeclamptic pregnancies. We measured the plasma levels of tissue plasminogen activator (tPA) antigen and of plasminogen activator inhibitor type 1 (PAI-1) antigen, both markers of hemostatic and endothelial function, and fibrin fragment D-dimer. Maternal blood from uncomplicated (n=42) and PEc pregnancies (n=44) were collected before delivery, and umbilical cord blood (UCB) immediately after delivery. In preeclamptic cases, UCB presented significantly higher tPA values and significantly lower PAI-1/tPA ratio. Preeclamptic women also presented significantly higher tPA, as well as PAI-1 values, when compared with normal pregnant women; no significant difference was found for D-dimer. In preeclamptic women, proteinuria (a marker of PE severity) correlated positively and significantly with tPA and PAI-1 antigen levels. <br> <br> KEYWORDS: Endothelial dysfunction; PAI-1; Preeclampsia; Pregnancy; tPA <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1C-4S62CFD-2&_user=2460038&_coverDate=12%2F31%2F2008&_rdoc=7&_fmt=high&_orig=browse&_srch=doc-info(%23toc%234887%232008%23998769997%23701432%23FLA%23display%23Volume)&_cdi=4887&_sort=d&_docanchor=&_ct=34&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=337b90915a196135d85df10bf32b3282"> Texto integral</a> <br> <br>

Abstract (EN): Endothelial cell activation or damage is believed to play a key rote in preeclampsia (PE) and may underlie the hemostatic changes observed in this syndrome. The aim of this study was to evaluate a relationship between maternal and cord blood hemostatic disturbances in preeclamptic pregnancies. We measured the plasma levels of tissue plasminogen activator (tPA) antigen and of plasminogen activator inhibitor type 1 (PAI-1) antigen, both markers of hemostatic and endothetial function, and fibrin fragment D-dimer. Maternal blood from uncomplicated (n=42) and PEc pregnancies (n=44) were collected before delivery, and umbilical cord blood (UCB) immediately after delivery. In preeclamptic cases, UCB presented significantly higher tPA values and significantly lower PAI-1/tPA ratio. Preeclamptic women also presented significantly higher tPA, as well as PAI-1 values, when compared with normal pregnant women; no significant difference was found for D-dimer. In preeclamptic women, proteinuria (a marker of PE severity) correlated positively and significantly with tPA and PAI-1 antigen levels. An inverse relationship between maternal tPA antigen levels and fetal birth weigh in PE was also observed. Our data show that the hemostatic maternal disturbances observed in preeclamptic women have similarities with the UCB circulation, and that endothetial dysfunction is the most plausible underlying cause. Moreover, maternal hemostatic disturbances seem to be associated with the severity of PE. Further studies are needed to strength the values of tPA and PAI-1 as markers of severity in PE.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6