UV-polymerizable methacrylated gelatin (GelMA)-based hydrogel containing tannic acids for wound healing

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

do Nascimento, MF (Autor) Outra; de Oliveira, CR (Autor) Outra; Cardoso, JC (Autor) Outra; Bordignon, NCT (Autor) Outra; Gondak, R (Autor) Outra; Severino, P (Autor) Outra; Souto, EB (Autor) FFUP; de Albuquerque , RLC (Autor) Outra

Revista

Título: Drug Delivery and Translational Research

Vol. 13

Páginas: 3223-3238

ISSN: 2190-393X

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 0 Citações

Scopus

Outras Informações

ID Authenticus: P-00Y-SCX

DOI: 10.1007/s13346-023-01383-y

Abstract (EN): Gelatin-based photopolymerizable methacrylate hydrogel (GelMA) is a promising biomaterial for in situ drug delivery, while aqueous extract of Punica granatum (AEPG) peel fruit rich in gallic acid and ellagic acid is used to improve wound healing. The aim of this study was to develop and analyze the healing properties of GelMA containing AEPG, gallic acid, or ellagic acid in a rodent model. GelMA hydrogels containing 5% AEPG (GelMA-GPG), 1.6% gallic acid (GelMA-GGA), or 2.1% ellagic acid (GelMA-GEA) were produced and their mechanical properties, enzymatic degradation, and thermogravimetric profile determined. Wound closure rates, healing histological grading, and immunohistochemical counts of myofibroblasts were assessed over time. The swelling of hydrogels varied between 50 and 90%, and GelMA exhibited a higher swelling than the other groups. The GPG samples showed higher compression and Young's moduli than GelMA, GGA, and GAE. All samples degraded around 95% in 48 h. GPG and GGA significantly accelerated wound closure, improved collagenization, increased histological grading, and hastened myofibroblast differentiation in comparison to the control, GelMA, and GEA. GelMA containing AEPG (GPG) improved wound healing, and although gallic acid is the major responsible for such biological activity, a potential synergic effect played by other polyphenols present in the extract is evident.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16