Psidium guajava L. phenolic compound-reinforced lamellar scaffold for tracheal tissue engineering

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Amaral, VA (Autor) Outra; de Souza, JF (Autor) Outra; Alves, TFR (Autor) Outra; de Oliveira, JMD (Autor) Outra; Severino, P (Autor) Outra; Aranha, N (Autor) Outra; Souto, EB (Autor) FFUP; Chaud, MV (Autor) Outra

Revista

Título: Drug Delivery and Translational Research

Vol. 14

Páginas: 62-79

ISSN: 2190-393X

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Y-WCP

DOI: 10.1007/s13346-023-01381-0

Abstract (EN): The aim of this work was to develop a dense lamellar scaffold, as a biomimetic material with potential applications in the regeneration of tracheal tissue after surgical tumor resection. The scaffolds were produced by plastic compression technique, exploiting the use of total phenolic compounds (TPC) from Psidium guajava Linn as a potential cross-linking agent in a polymeric mixture based on collagen (COL), silk fibroin (SF), and polyethylene glycol 400 (PEG 400). Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) confirmed the chemical interactions between the polymers and the cross-linking of TPC between COL and SF. Morphological analyses showed scaffolds with porosity, inter-connectivity, and a porous surface structure with a gyroid-like geometry. The analysis of the anisotropic degree resulted in anisotropic structures (0.1% TFC and 0.3% TFC) and an isotropic structure (0.5% TFC). In the mechanical properties, it was evidenced greater resistance for the 0.3% TFC formulation. The addition of TPC percentages did not result in a significant difference (p > 0.05) in swelling capacity and disintegration rate. The results confirmed that TPC were able to modulate the morphological, morphometric, and mechanical properties of scaffolds. Thus, this study describes a potential new material to improve the regeneration of major tracheal structures after surgical tumor removal.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 18