From waste to bioactive compounds: A response surface methodology approach to extract antioxidants from Pistacia vera shells for postprandial hyperglycaemia management

• Tipo: Artigo em Revista Científica Internacional
• Data: 2024

Autores

Maccarronello, AE (Autor) Outra; Cardullo, N (Autor) Outra; Silva, AM (Autor) Outra; Di Francesco, A (Autor) Outra; Paulo Costa (Autor) FFUP; Rodrigues, F (Autor) Outra; Muccilli, V (Autor) Outra

Revista

Título: Food Chemistry

Vol. 443

ISSN: 0308-8146

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Z-XD7

DOI: 10.1016/j.foodchem.2024.138504

Abstract (EN): Pistacia vera shells, an abundant agricultural by-product, are a rich source of undiscovered bioactive compounds. This study employed a response surface methodology (RSM) approach to optimize the microwave-assisted extraction of antioxidants. The highest total phenolic content, and antioxidant activity were achieved under the optimized extraction conditions (20 % ethanol, 1000 W, 135 s, and solvent-to-solid ratio of 27 mL/g). The resulting extract (OPVS-E) included gallic acid derivatives, hydrolysable tannins, flavonoids, fatty acids, and anacardic acids. Remarkably, OPVS-E displayed potent inhibitory activity against alpha-amylase (IC50 = 2.05 mu g/mL) and alpha-glucosidase (IC50 = 41.07 mu g/mL), by far more powerful than the anti-diabetic drug acarbose, OPVS-E exhibited a strong antiradical capacity against reactive oxygen species (ROS) without causing toxicity in intestinal cells (HT29-MTX and Caco-2). These findings introduce OPVS-E as a potential novel dual-action nutraceutical ingredient, able to mitigate postprandial hyperglycemia and counteract the ROS overproduction occurring in type 2 diabetes mellitus.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13