In vitro mineralisation of human bone marrow cells cultured on Bonelike®

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

M. A. Costa (Autor) Outra; M. Gutierres (Autor) Outra; L. Almeida (Autor) Outra; Maria Ascensão Lopes (Autor) FEUP; José Domingos Santos (Autor) FEUP; M. H. Fernandes (Autor) Outra

Revista

Título: Key Engineering Materials

Vol. 254-256

Páginas: 821-823

ISSN: 1013-9826

Editora: Trans Tech Publications Ltd

Indexação

ISI Web of Science

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia médica

Outras Informações

DOI: 10.4028/www.scientific.net/KEM.254-256.821

Abstract (EN): Bonelike(R) is a CaO-P2O5 based glass-reinforced hydroxyapatite (HA) designed to mimic the inorganic composition of the bone tissue. This work evaluates the response of human bone marrow cells to Bonelike(R) concerning cell proliferation and osteoblast differentiation. HA was used as control material. Results showed that Bonelike(R) allowed the proliferation of bone marrow cells and their complete differentiation, as evidenced by the formation of cell-mediated mineralisation. In comparison with HA, Bonelike(R) had a positive effect on the expression of alkaline phosphatase and also on the formation of a mineralised matrix, two osteoblast markers.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3