Uncovering the Metabolic Footprint of New Psychoactive Substances by Metabolomics: A Systematic Review

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2025

Autores

Almeida, AS (Autor) Outra; de Pinho, PG (Autor) FFUP; Fernando Remiao (Autor) FFUP; Carla Fernandes (Autor) FFUP

Revista

Título: Molecules

Vol. 30

Página Final: 290

ISSN: 1420-3049

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-017-SVW

DOI: 10.3390/molecules30020290

Abstract (EN): New psychoactive substances (NPSs) emerged in the 2000s as legal alternatives to illicit drugs and quickly became a huge public health threat due to their easy accessibility online, limited information, and misleading labels. Synthetic cannabinoids and synthetic cathinones are the most reported groups of NPSs. Despite NPSs being widely studied, due to their structural diversity and the constant emergence of novel compounds with unknown properties, the development of new techniques is required to clarify their mode of action and evaluate their toxicological effects. Metabolomics has been a useful tool to evaluate the metabolic effects of several xenobiotics. Herein, a systematic review was performed, following PRISMA guidelines, regarding metabolomic studies on synthetic cathinones and synthetic cannabinoids to evaluate their effects in cellular metabolism. In the studies, in vivo models were the most employed (86%) and the analysis mostly followed untargeted approaches (75%) using LC-MS techniques (67%). Both groups of NPSs seem to primarily interfere with energy metabolism-related pathways. Even though this type of study is still limited, metabolomics holds great promise as a tool to clarify mechanisms of actions, identify biomarkers of exposure, and explain the toxicological effects of NPSs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 22