Therapeutic Potential of Marine-Derived Cyclic Peptides as Antiparasitic Agents

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Ribeiro, R (Autor) Outra; Costa, L (Autor) Outra; Eugenia Pinto (Autor) FFUP; Emilia Sousa (Autor) FFUP; Carla Fernandes (Autor) FFUP; Fernandez, J (Autor) Outra

Revista

Título: Marine Drugs

Vol. 12

Página Final: 609

ISSN: 1660-3397

Editora: MDPI

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 4 Citações

Outras Informações

ID Authenticus: P-00Z-R33

DOI: 10.3390/md21120609

Abstract (EN): Parasitic diseases still compromise human health. Some of the currently available therapeutic drugs have limitations considering their adverse effects, questionable efficacy, and long treatment, which have encouraged drug resistance. There is an urgent need to find new, safe, effective, and affordable antiparasitic drugs. Marine-derived cyclic peptides have been increasingly screened as candidates for developing new drugs. Therefore, in this review, a systematic analysis of the scientific literature was performed and 25 marine-derived cyclic peptides with antiparasitic activity (1-25) were found. Antimalarial activity is the most reported (51%), followed by antileishmanial (27%) and antitrypanosomal (20%) activities. Some compounds showed promising antiparasitic activity at the nM scale, being active against various parasites. The mechanisms of action and targets for some of the compounds have been investigated, revealing different strategies against parasites.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 27