Toxicity Mechanisms of Gadolinium and Gadolinium-Based Contrast Agents-A Review

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2024

Autores

Coimbra, S (Autor) Outra; Rocha, S (Autor) Outra; Sousa, NR (Autor) Outra; Cristina Catarino (Autor) FFUP; Belo, L (Autor) FFUP; Bronze da Rocha, E (Autor) FFUP; Valente, MJ (Autor) Outra; Santos-Silva, A (Autor) Outra

Revista

Título: International Journal Of Molecular Sciences

Vol. 25

Página Final: 4071

ISSN: 1661-6596

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-010-9XP

DOI: 10.3390/ijms25074071

Abstract (EN): Gadolinium-based contrast agents (GBCAs) have been used for more than 30 years to improve magnetic resonance imaging, a crucial tool for medical diagnosis and treatment monitoring across multiple clinical settings. Studies have shown that exposure to GBCAs is associated with gadolinium release and tissue deposition that may cause short- and long-term toxicity in several organs, including the kidney, the main excretion organ of most GBCAs. Considering the increasing prevalence of chronic kidney disease worldwide and that most of the complications following GBCA exposure are associated with renal dysfunction, the mechanisms underlying GBCA toxicity, especially renal toxicity, are particularly important. A better understanding of the gadolinium mechanisms of toxicity may contribute to clarify the safety and/or potential risks associated with the use of GBCAs. In this work, a review of the recent literature concerning gadolinium and GBCA mechanisms of toxicity was performed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 22