In vivo behaviour of Bonelike((R))/PLGA hybrid: Histological analysis and peripheral quantitative computed tomography (pQ-CT) evaluation

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Oliveira, JM (Autor) Outra; Kawai, T (Autor) Outra; Lopes, MA (Autor) FEUP; Ohtsuki, C (Autor) Outra; Santos, JD (Autor) FEUP; Américo Afonso (Autor) FMDUP

Revista

Título: Key Engineering Materials

Vol. 254-256

Páginas: 565-568

ISSN: 1013-9826

Editora: Trans Tech Publications Ltd

Indexação

ISI Web of Knowledge - 1 Citação

ISI Web of Science

Scopus - 1 Citação

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Biotecnologia ambiental

CORDIS: Ciências Tecnológicas > Engenharia > Engenharia de biomateriais

Outras Informações

ID Authenticus: P-000-CBF

DOI: 10.4028/www.scientific.net/KEM.254-256.565.

Abstract (EN): The present work consisted in assessing the in vivo biological behaviour of novel Bonelike(R)/PLGA hybrid materials through subcutaneous and tibiae implantations for a 4 week period using an animal model. No sign of inflammation was observed as a result of subcutaneous implantation, which reveals that these materials were well-tolerated by the soft tissues. pQ-CT analysis demonstrated that the implanted materials were highly osteointegrated in bone tissue. SEM analysis at bone defect area revealed that Bonelike(R) resorption occurred after 4 weeks of implantation. Although the osteoconductive properties of Bonelike(R) have been reported in literature, the present work allowed to demonstrate that the silane-coupling agent and the PLGA treatments do not significantly modify the biological performance of Bonelike(R). This result is strongly encouraging since Bonelike(R)/PLGA hybrid materials are being developed for bone tissue healing/regeneration purposes with simultaneous delivery of therapeuthic molecules.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4