Integrated Study of Canine Mammary Tumors Histopathology, Immunohistochemistry, and Cytogenetic Findings

• Tipo: Artigo em Revista Científica Internacional
• Data: 2024

Autores

Ferreira, T (Autor) Outra; Miranda, M (Autor) Outra; Pinto-Leite, R (Autor) Outra; Mano, JF (Autor) Outra; Rui Medeiros (Autor) ICBAS; Oliveira, PA (Autor) Outra; Gama, A (Autor) Outra

Revista

Título: VETERINARY SCIENCES

Vol. 11

Página Final: 409

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-017-034

DOI: 10.3390/vetsci11090409

Abstract (EN): Simple Summary Canine mammary tumors are the most common tumor in intact female dogs. This study aimed to investigate the clinicopathological, immunohistochemical, and cytogenetic features of canine mammary tumors. This study is relevant due to the fact that canine and human breast cancer share similar epidemiological and histopathological characteristics, reinforcing the potential for dogs to serve as an effective animal model for human breast cancer research.Abstract Cancer is a complex pathological condition associated with substantial rates of mortality and morbidity in both humans and animals. Mammary gland tumors in intact female dogs are the most prevalent neoplasms. Surgical intervention remains the primary treatment choice. Alternative therapeutic options have emerged, with histopathological examination being fundamental to confirm the diagnosis and to decide the best therapy. This research focused on the clinicopathological, immunohistochemical, and cytogenetic aspects of canine mammary tumors (CMTs). Most of the animals were mixed-breed, with the majority being older than seven years, and only 16.7% had been spayed before surgery. Caudal abdominal and inguinal mammary glands were the most affected, with regional mastectomy being the predominant treatment (75.0%). Of all the tumors, 29.1% were benign, while 70.9% were malignant. Complex adenoma was the most common benign tumor, whereas tubulopapillary carcinoma was the most common malignant type. Grade III tumors (17.6%) were the least encountered, while grades I and II exhibited a similar prevalence (41.2%). All the carcinomas were classified as luminal, and cytogenetics analysis demonstrated a high chromosomal instability with significant aneuploidy observed in all cases and polyploidy detected in 62.5%. This study holds significance as canine and human breast cancers share similar characteristics, suggesting that dogs could be a valuable model for human breast cancer research. Further studies with larger sample sizes are needed to enhance our understanding of CMTs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15