TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Costa, AI (Autor) Outra; Gemini Piperni, S (Autor) Outra; Alves, AC (Autor) FEUP; Costa, NA (Autor) Outra; Checca, NR (Autor) Outra; Leite, PE (Autor) Outra; Rocha, LA (Autor) Outra; Pinto, AMP (Autor) Outra; Toptan, F (Autor) Outra; Rossi, AL (Autor) Outra; Ribeiro, AR (Autor) Outra

Revista

Título: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

Vol. 120

ISSN: 0928-4931

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00T-2ZC

DOI: 10.1016/j.msec.2020.111735

Abstract (EN): One of the main problems that remain in the implant industry is poor osseointegration due to bioinertness of implants. In order to promote bioactivity, calcium (Ca), phosphorus (P) and strontium (Sr) were incorporated into a TiO2 porous layer produced by micro-arc oxidation. Ca and P as bioactive elements are already well reported in the literature, however, the knowledge of the effect of Sr is still limited. In the present work, the effect of various amounts of Sr was evaluated and the morphology, chemical composition and crystal structure of the oxide layer were investigated. Furthermore, in vitro studies were carried out using human osteoblast-like cells. The oxide layer formed showed a triplex structure, where higher incorporation of Sr increased Ca/P ratio, amount of rutile and promoted the formation of SrTiO3 compound. Biological tests revealed that lower concentrations of Sr did not compromise initial cell adhesion neither viability and interestingly improved mineralization. However, higher concentration of Sr (and consequent higher amount of rutile) showed to induce collagen secretion but with compromised mineralization, possibly due to a delayed mineralization process or induced precipitation of deficient hydroxyapatite. Ca-P-TiO2 porous layer with less concentration of Sr seems to be an ideal candidate for bone implants.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11