Assessing medication use patterns by clinical outcomes severity among inpatients with COVID-19: A retrospective drug utilization study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2024

Autores

Ferreira-da-Silva, R (Autor) FMUP; Maranhao, P (Autor) Outra; Dias, CC (Autor) Outra; Alves, JM (Autor) FMUP; Pires, L (Autor) Outra; Morato, M (Autor) FFUP; Polónia, JJ (Autor) Outra; Ribeiro-Vaz, I (Autor) Outra

Revista

Título: Biomedicine & Pharmacotherapy

Vol. 172

ISSN: 0753-3322

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Z-X54

DOI: 10.1016/j.biopha.2024.116242

Abstract (EN): Purpose: This study assessed medication patterns for inpatients at a central hospital in Portugal and explored their relationships with clinical outcomes in COVID-19 cases. Methods: A retrospective study analyzed inpatient medication data, coded using the Anatomical Therapeutic Chemical classification system, from electronic patient records. It investigated the association between medications and clinical severity outcomes such as ICU admissions, respiratory/circulatory support needs, and hospital discharge status, including mortality (identified by ICD-10-CM/PCS codes). Multivariate analyses incorporating demographic data and comorbidities were used to adjust for potential confounders and understand the impact of medication patterns on disease progression and outcomes. Results: The analysis of 2688 hospitalized COVID-19 patients (55.3% male, average age 62.8 years) revealed a significant correlation between medication types and intensity and disease severity. Cases requiring ICU admission or ECMO support often involved blood and blood-forming organ drugs. Increased use of nervous system and genitourinary hormones was observed in nonsurvivors. Corticosteroids, like dexamethasone, were common in critically ill patients, while tocilizumab was used in ECMO cases. Medications for the alimentary tract, metabolism, and cardiovascular system, although widely prescribed, were linked to more severe cases. Invasive mechanical ventilation correlated with higher usage of systemic anti-infectives and musculoskeletal medications. Trends in co-prescribing blood-forming drugs with those for acid-related disorders, analgesics, and antibacterials were associated with intensive interventions and worse outcomes. Conclusions: The study highlights complex medication regimens in managing severe COVID-19, underscoring specific drug patterns associated with critical health outcomes. Further research is needed to explore these patterns.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15