Gastric neuroendocrine neoplasm with late liver metastasis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Marques, B (Autor) Outra; R Martins (Autor) FMUP; Tralhao, G (Autor) Outra; Couto, J (Autor) Outra; Saraiva, S (Autor) Outra; Ferrao, H (Autor) Outra; Ribeiro, J (Autor) Outra; Santos, J (Autor) Outra; Martins, T (Autor) Outra; Cadime, AT (Autor) Outra; Rodrigues, F (Autor) Outra

Revista

Título: Endocrinology, Diabetes and Metabolism Case Reports

Vol. 2018

Páginas: 1-5

Editora: BioScientifica Ltd.

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 5 Citações

Outras Informações

ID Authenticus: P-00P-JRK

DOI: 10.1530/edm-18-0048

Abstract (EN): Gastric neuroendocrine neoplasms (GNENs) are classified into three types according to their aetiology. We present a clinical case of a female patient of 66 years and a well-differentiated (grade 2), type 3 GNEN with late liver metastasis (LM). The patient underwent surgical excision of a gastric lesion at 50 years of age, without any type of follow-up. Sixteen years later, she was found to have a neuroendocrine tumour (NET) metastatic to the liver. The histological review of the gastric lesion previously removed confirmed that it was a NET measuring 8 mm, pT1NxMx (Ki67 = 4%). Ga-68-DOTANOC PET/CT reported two LM and a possible pancreatic tumour/gastric adenopathy. Biopsies of the lesion were repeatedly inconclusive. She had a high chromogranin A, normal gastrin levels and negative anti-parietal cell and intrinsic factor antibodies, which is suggestive of type 3 GNEN. She underwent total gastrectomy and liver segmentectomies (segment IV and VII) with proven metastasis in two perigastric lymph nodes and both with hepatic lesions (Ki67 = 5%), yet no evidence of local recurrence. A Ga-68-DOTANOC PET/CT was performed 3 months after surgery, showing no tumour lesions and normalisation of CgA. Two years after surgery, the patient had no evidence of disease. This case illustrates a rare situation, being a type 3, well-differentiated (grade 2) GNEN, with late LM. Despite this, it was possible to perform surgery with curative intent, which is crucial in these cases, as systemic therapies have limited efficacy. We emphasise the need for extended follow-up in these patients.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5