Gastrointestinal effects of caffeine in preterm infants: a systematic review and Bayesian meta-analysis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2024

Autores

Gama, B (Autor) Outra; von Hafe, M (Autor) Outra; Vieira, R (Autor) FMUP; Soares, H (Autor) Outra; Inês Azevedo (Autor) FMUP; Rocha, G (Autor) Outra

Revista

Título: Archives of Disease in Childhood: Fetal and Neonatal Edition

Vol. 109

Páginas: 670-676

ISSN: 1359-2998

Editora: BMJ PUBLISHING GROUP

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-010-A68

DOI: 10.1136/archdischild-2024-327075

Abstract (EN): Objective Caffeine is widely used in preterm infants to prevent or treat apnoea of prematurity. Adverse gastrointestinal effects of caffeine have not been thoroughly researched in preterm infants. With this systematic review and meta-analysis, we aim to summarise the results of trials on the gastrointestinal effects of caffeine in preterm infants. Design We searched MEDLINE, Web of Science, Scopus and ClinicalTrials.gov up to 21 April 2023. We included randomised controlled trials assessing caffeine versus placebo in preterm neonates and reporting gastrointestinal side effects. Risk of bias was assessed using the Cochrane Risk of Bias tool. A Bayesian meta-analysis was performed to estimate the pooled OR of gastrointestinal side effects. Results Nine trials involving 2746 preterm infants were analysed. Seven trials assessing necrotising enterocolitis and four trials assessing feeding intolerance in our meta-analysis found no differences between caffeine and placebo (OR=1.007 (95% credible interval 0.021, 5.462), I2=97.4%, and OR=1.266 (95% credible interval 0.064, 28.326), I2=84.8%, respectively). Four trials assessed the outcomes spontaneous intestinal perforation, constipation, gastrointestinal disorder (composite outcome: gastro-oesophageal regurgitation or dilated bowel loops), age at oral feeding and cholestasis syndrome and found no differences between groups. One trial assessed the outcomes gastro-oesophageal symptoms and duration of tube feeding and found that caffeine was associated with a reduced burden of gastro-oesophageal reflux symptoms at 2 weeks (p<0.05), but not at term. Conclusions According to this systematic review and meta-analysis, the use of caffeine at usual doses in preterm infants does not seem to be associated with significant gastrointestinal adverse effects.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7