2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for granulomatosis with polyangiitis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Robson, JC (Autor) Outra; Grayson, PC (Autor) Outra; Ponte, C (Autor) Outra; Suppiah, R (Autor) Outra; Craven, A (Autor) Outra; Judge, A (Autor) Outra; Khalid, S (Autor) Outra; Hutchings, A (Autor) Outra; Watts, RA (Autor) Outra; Merkel, PA (Autor) Outra; Luqmani, RA (Autor) Outra; Elsa Azevedo (Autor) FMUP

Revista

Título: Annals of the Rheumatic Diseases

Vol. 81

Páginas: 315-320

ISSN: 0003-4967

Editora: BMJ PUBLISHING GROUP

Indexação

Scopus - 178 Citações

Outras Informações

ID Authenticus: P-00W-6P2

DOI: 10.1136/annrheumdis-2021-221795

Abstract (EN): OBJECTIVE: To develop and validate revised classification criteria for granulomatosis with polyangiitis (GPA). METHODS: Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in five phases: (1) identification of candidate criteria items using consensus methodology, (2) prospective collection of candidate items present at the time of diagnosis, (3) data-driven reduction of the number of candidate items, (4) expert panel review of cases to define the reference diagnosis and (5) derivation of a points-based risk score for disease classification in a development set using least absolute shrinkage and selection operator logistic regression, with subsequent validation of performance characteristics in an independent set of cases and comparators. RESULTS: The development set for GPA consisted of 578 cases of GPA and 652 comparators. The validation set consisted of an additional 146 cases of GPA and 161 comparators. From 91 candidate items, regression analysis identified 26 items for GPA, 10 of which were retained. The final criteria and their weights were as follows: bloody nasal discharge, nasal crusting or sino-nasal congestion (+3); cartilaginous involvement (+2); conductive or sensorineural hearing loss (+1); cytoplasmic antineutrophil cytoplasmic antibody (ANCA) or anti-proteinase 3 ANCA positivity (+5); pulmonary nodules, mass or cavitation on chest imaging (+2); granuloma or giant cells on biopsy (+2); inflammation or consolidation of the nasal/paranasal sinuses on imaging (+1); pauci-immune glomerulonephritis (+1); perinuclear ANCA or antimyeloperoxidase ANCA positivity (-1); and eosinophil count ¿1×109¿/L (-4). After excluding mimics of vasculitis, a patient with a diagnosis of small- or medium-vessel vasculitis could be classified as having GPA if the cumulative score was ¿5 points. When these criteria were tested in the validation data set, the sensitivity was 93% (95% CI 87% to 96%) and the specificity was 94% (95% CI 89% to 97%). CONCLUSION: The 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for GPA demonstrate strong performance characteristics and are validated for use in research. © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

Idioma: Inglês

Tipo (Avaliação Docente): Científica