Treatment-shortening regimens for tuberculosis: updates and future priorities

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Saluzzo, F (Autor) Outra; Adepoju, VA (Autor) Outra; Duarte R (Autor) ICBAS; Lange, C (Autor) Outra; Phillips, PPJ (Autor) Outra

Revista

Título: Breathe

Vol. 19

ISSN: 1810-6838

Editora: European Respiratory Society

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 5 Citações

Outras Informações

ID Authenticus: P-00Z-GFM

DOI: 10.1183/20734735.0028-2023

Abstract (EN): In the past 2 years, remarkable advances have been made in shortening tuberculosis (TB) treatment. In particular, four clinical trials (Study 31/A5349, Nix-TB, ZeNix and TB-PRACTECAL) have provided evidence of the efficacy of regimens based on new and repurposed drugs: the 4-month regimen for drug -susceptible TB, and the 6-month bedaquiline-pretomanid-linezolid regimen with or without moxifloxacin for multidrug-resistant/rifampicin-resistant TB. Even if the evidence at the basis of these new regimens is compelling, several questions remain open, particularly concerning linezolid dose finding, the upsurging threat of bedaquiline-resistant Mycobacterium tuberculosis and the feasibility of applying these results to the paediatric population. Several ongoing trials may fill the remaining gaps and produce further reliable evidence to address the outstanding questions in TB treatment shortening.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7