Connecting Circuits for Supraspinal Control of Locomotion

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Ferreira-Pinto, MJ (Autor) FMUP; Ruder, L (Autor) Outra; Capelli, P (Autor) Outra; Arber, S (Autor) Outra

Revista

Título: Neuron

Vol. 100

Páginas: 361-374

ISSN: 0896-6273

Editora: Elsevier

Indexação

ISI Web of Knowledge - 78 Citações

Scopus - 81 Citações

Outras Informações

ID Authenticus: P-00Z-ZNF

DOI: 10.1016/j.neuron.2018.09.015

Abstract (EN): Locomotion is regulated by distributed circuits and achieved by the concerted activation of body musculature. While the basic properties of executive circuits in the spinal cord are fairly well understood, the precise mechanisms by which the brain impacts locomotion are much less clear. This Review discusses recent work unraveling the cellular identity, connectivity, and function of supraspinal circuits. We focus on their involvement in the regulation of the different phases of locomotion and their interaction with spinal circuits. Dedicated neuronal populations in the brainstem carry locomotor instructions, including initiation, speed, and termination. To align locomotion with behavioral needs, brainstem output structures are recruited by midbrain and forebrain circuits that compute and infer volitional, innate, and context-dependent locomotor properties. We conclude that the emerging logic of supraspinal circuit organization helps to understand how locomotor programs from exploration to hunting and escape are regulated by the brain. Ferreira-Pinto et al. discuss recent work unraveling cellular identity, connectivity, and function of brain circuits orchestrating locomotion. Context-adequate forms of locomotion¿from exploration to escape¿are implemented by precise interactions between dedicated neuronal populations connecting forebrain, brainstem, and spinal circuits.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14