Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Almeida, L (Autor) Outra; Vaz Da Silva, M (Autor) FMUP; Falcao, A (Autor) Outra; Soares, E (Autor) Outra; Costa, R (Autor) Outra; Loureiro, AI (Autor) Outra; Fernandes Lopes, C (Autor) Outra; Rocha, JF (Autor) Outra; Nunes, T (Autor) Outra; Wright, L (Autor) Outra; soares-da-silva, p (Autor) FMUP

Revista

Título: Molecular Nutrition and Food Research

Vol. 53

Páginas: S7-S15

ISSN: 1613-4125

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 373 Citações

Scopus - 404 Citações

Outras Informações

ID Authenticus: P-003-KJ7

DOI: 10.1002/mnfr.200800177

Abstract (EN): This was a double-blind, randomised, placebo-controlled study to investigate the pharmacokinetics and safety of trans-resveratrol. In four groups of ten healthy adult subjects ( five males and five females), two subjects were randomized to receive placebo and eight subjects to receive trans-resveratrol 25, 50, 100 or 150 mg, six times/day, for thirteen doses. Peak plasma concentrations of trans-resveratrol were reached at 0.8-1.5 h postdose. Following the 13th dose of trans-resveratrol 25, 50, 100 and 150 mg, mean peak plasma concentration (C(max)) was 3.89, 7.39, 23.1 and 63.8 ng/mL and mean area under the plasma concentration-time curve (AUC(0-tau)) was 3.1, 11.2, 33.0 and 78.9 ng . h/mL. Interindividual variability was high, with coefficients of variation >40%. Trans-resveratrol half-life was 1-3 h following single-doses and 2-5 h following repeated dosing. Trough (C(min)) concentrations were <= 1 ng/mL following 25 and 50 mg, 3 ng/mL following 100 mg and <10 ng/mL following 150 mg. Trans-resveratrol pharmacokinetics showed circadian variation. Adverse events were mild in severity and similar between all groups. In conclusion, repeated administration was well-tolerated but produced relatively low plasma concentrations of trans-resveratrol, despite the high doses and short dosing interval used. Bioavailability was higher after morning administration.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9