Thrombosis and cachexia in cancer: Two partners in crime?

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2023

Autores

Liz-Pimenta, J (Autor) Outra; Tavares, V (Autor) Outra; Neto, BV (Autor) Outra; Santos, JMO (Autor) Outra; Guedes, CB (Autor) Outra; Araujo, A (Autor) Outra; Khorana, AA (Autor) Outra; Rui Medeiros (Autor) ICBAS

Revista

Título: Critical Reviews in Oncology/Hematology

Vol. 186

ISSN: 1040-8428

Editora: Elsevier

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 7 Citações

Outras Informações

ID Authenticus: P-00Y-9GV

DOI: 10.1016/j.critrevonc.2023.103989

Abstract (EN): Among cancer patients, thrombosis and cachexia are major causes of morbidity and mortality. Although the two may occur together, little is known about their possible relationship. Thus, a literature review was conducted by screening the databases PubMed, Scopus, SciELO, Medline and Web of Science. To summarize, cancer-associated thrombosis (CAT) and cancer-associated cachexia (CAC) seem to share several patient-, tumour- and treatmentrelated risk factors. Inflammation alongside metabolic and endocrine derangement is the potential missing link between CAT, CAC and cancer. Many key players, including specific pro-inflammatory cytokines, immune cells and hormones, appear to be implicated in both thrombosis and cachexia, representing attractive predictive markers and potential therapeutic targets. Altogether, the current evidence suggests a link between CAT and CAC, however, epidemiological studies are required to explore this potential relationship. Given the high incidence and negative impact of both diseases, further studies are needed for the better management of cancer patients.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15