Corino de Andrade disease: mechanisms and impact on reproduction

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2017

Autores

Lopes, RA (Autor) Outra; Coelho, T (Autor) Outra; barros, a (Autor) FMUP; sousa, m (Autor) ICBAS

Revista

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Título: JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA

Vol. 21

Páginas: 105-114

ISSN: 1517-5693

Editora: SOC BRASILEIRA REPRODUCAO ASSISTIDA-SBRA

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 4 Citações

Outras Informações

ID Authenticus: P-00M-Z3H

DOI: 10.5935/1518-0557.20170025

Abstract (EN): Familial amyloid polyneuropathy was first described by Corino de Andrade in 1952 in Northern Portugal. It is a fatal autosomal dominant neurodegenerative disorder characterized by a progression of neurologic symptoms, beginning early in the reproductive life. The Transthyretin gene mutation originates a mutated protein that precipitates in the connective tissue as amyloid deposits. This disease is presently named Transthyretin-related hereditary amyloidosis. We performed an extensive review on this disease based on searches in Medical databases and in paper references. In this review, we briefly summarize the epidemiology and the mechanisms involved on amyloid deposition; we detailed how to evaluate the mechanisms implicated on the development of the major signs and symptoms associated with reproductive dysfunction; and we discuss the mechanisms involved in secondary sexual dysfunction after psychological treatments. Treatment of the disease is directed towards relieving specific symptoms in association with liver transplant, and molecular and genetic therapeutics. Although the current clinical trials indicate symptoms relief, no data on the reproductive function was reported. Thus, preimplantation genetic diagnosis is presently the only available technique that eradicates the disease as it avoids the birth of new patients.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10