Thiocoumarins: From the Synthesis to the Biological Applications

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2022

Autores

Matos, MJ (Autor) FCUP; Santana, L (Autor) Outra; Uriarte, E (Autor) Outra; Fernanda Borges (Autor) FCUP

Revista

Título: Molecules

Nº de Série 3 Vol. 27 Nº 969

Página Final: 4901

ISSN: 1420-3049

Editora: MDPI

Indexação

ISI Web of Knowledge - 3 Citações

Scopus

Outras Informações

ID Authenticus: P-00X-2JC

DOI: 10.3390/molecules27154901

Abstract (EN): Coumarin is a privilege scaffold in medicinal chemistry. Coumarin derivatives are still an emerging class of highly potent pharmaceutical drugs, best known in the field of antimicrobials and anticoagulants. Thiocoumarins are a particular class of coumarins in which one or two of the oxygen atoms are replaced by a sulfur. They are chemically subdivided in three groups: Thiocoumarins, 2-thioxocoumarins, and dithiocoumarins. This review emphasizes the rationale behind the synthesis and biological applications of the most relevant publications related to this family of compounds. Particular attention has been given to their potential as drug candidates, with particular emphasis in the last 5 years. This article is based on the most relevant information collected from multiple electronic databases, including SciFinder, Pubmed, Espacenet, and Mendeley.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10