Excess Mortality in Kidney and Kidney-Pancreas Transplant Recipients in the COVID-19 Pandemic in Portugal-A Cohort Study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Coimbra, M (Autor) FCUP; Francisco, JATS (Autor) Outra; Freitas, JC (Autor) Outra; Carvalho, RV (Autor) Outra; Vilela, SRB (Autor) Outra; Ribeiro, CICD (Autor) Outra; Silvano, JLCSL (Autor) Outra; Pedroso, S (Autor) Outra; Almeida, M (Autor) Outra; Martins, L (Autor) Outra; Malheiro, J (Autor) Outra

Revista

Título: Transplant International

Vol. 36

ISSN: 0934-0874

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Z-8NP

DOI: 10.3389/ti.2023.11655

Abstract (EN): The COVID-19 pandemic increased morbidity and mortality worldwide, particularly in the Kidney and Kidney-Pancreas Transplant Recipient (KTR/KPTR) population. Aiming at assessing the absolute and relative excess mortality (EM) in a Portuguese KTR/KPTR cohort, we conducted a retrospective observational study of two KTR/KPTRs cohorts: cohort 1 (P1; n = 2,179) between September/2012 and March/2020; cohort 2 (P2; n = 2067) between March/2020, and August/2022. A correlation between relative and absolute EM and age, sex, time from transplantation and cause of death was explored. A total of 145 and 84 deaths by all causes were observed in P1 and P2, respectively. The absolute EM in P2 versus P1 was 19.2 deaths (observed/expected mortality ratio 1.30, p = 0.006), and the relative EM was 1.47/1,000 person-months (95% CI 1.11-1.93, p = 0.006). Compared to the same period in the general population, the standardized mortality rate by age in P2 was 3.86 (95% CI 2.40-5.31), with a peak at 9.00 (95% CI 4.84-13.16) in P2C. The higher EM identified in this population was associated, mainly, with COVID-19 infection, with much higher values during the second seasonal COVID-19 peak when compared to the general population, despite generalized vaccination. These highlight the need for further preventive measures and improved therapies in these patients.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10