New insight into antimicrobial activities of Linaria ventricosa essential oil and its synergetic effect with conventional antibiotics

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Nafis, A (Autor) Outra; Saad, FE (Autor) Outra; Khalloufi, FE (Autor) Outra; Kasrati, A (Autor) Outra; Abbad, A (Autor) Outra; Mezrioui, N (Autor) Outra; Oudra, B (Autor) Outra; Vitor Vasconcelos (Autor) FCUP; Hassani, L (Autor) Outra

Revista

Título: Archives of Microbiology

Vol. 203

Páginas: 4361-4366

ISSN: 0302-8933

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 4 Citações

Outras Informações

ID Authenticus: P-00V-2JJ

DOI: 10.1007/s00203-021-02391-7

Abstract (EN): The purpose of the present study was to determine for the first time the volatile constituents, the antioxidant and antimicrobial activities of the essential oil (EO) of the endemic Moroccan Linaria ventricosa, alone or in combination with four known antibiotics. The major constituents were 2-methoxy-4-vinylphenol (17.4%), alpha-terpinene (13.64%) and 3,5-dimethylphenyl isocyanate (12.21%). The EO had moderate antioxidant potency, as measured by DPPH free radical scavenging (1.233 +/- 0.031 mg/mL), ferric reducing antioxidant power assay (0.373 +/- 0.019 mg/mL) and beta-carotene/linoleic acid (0.922 +/- 0.026 mg/mL). EO showed microbicidal activity against all microorganisms tested. The highest effectiveness was recorded against Candida albicans (IZ = 24 mm, MIC = 4.87 mg/mL and MMC = 9.75 mg/mL) and Candida glabrata (IZ = 22 mm, MIC = MMC = 4.87 mg/mL). Gram negative bacteria were the most resistant (MIC = MMC = 39 mg/mL). The combination of EO at sub-inhibitory concentrations with antibiotics showed a significant decrease in their individual MICs from 2 to 128 fold, being the best for ciprofloxacin and fluconazole against E. coli and C. albicans and C. glabrata, respectively.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6