Injectable Poloxamer Hydrogels for Local Cancer Therapy

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2023

Autores

Marques, AC (Autor) FFUP; Paulo Costa (Autor) FFUP; Velho, S (Autor) Outra; Amaral, MH (Autor) Outra

Revista

Título: GELS

Vol. 10

Página Final: 593

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Y-S0E

DOI: 10.3390/gels9070593

Abstract (EN): The widespread push to invest in local cancer therapies comes from the need to overcome the limitations of systemic treatment options. In contrast to intravenous administration, local treatments using intratumoral or peritumoral injections are independent of tumor vasculature and allow high concentrations of therapeutic agents to reach the tumor site with minimal systemic toxicity. Injectable biodegradable hydrogels offer a clear advantage over other delivery systems because the former requires no surgical procedures and promotes drug retention at the tumor site. More precisely, in situ gelling systems based on poloxamers have garnered considerable attention due to their thermoresponsive behavior, biocompatibility, ease of preparation, and possible incorporation of different anticancer agents. Therefore, this review focuses on the use of injectable thermoresponsive hydrogels based on poloxamers and their physicochemical and biological characterization. It also includes a summary of these hydrogel applications in local cancer therapies using chemotherapy, phototherapy, immunotherapy, and gene therapy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15