Cadherins Glycans in Cancer: Sweet Players in a Bitter Process

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2016

Autores

Carvalho, S (Autor) Outra; Celso Reis (Autor) ICBAS; Pinho, SS (Autor) Outra

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: TRENDS IN CANCER

Vol. 2

Páginas: 519-531

ISSN: 2405-8033

Editora: CELL PRESS

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 24 Citações

Outras Informações

ID Authenticus: P-00R-B57

DOI: 10.1016/j.trecan.2016.08.003

Abstract (EN): Cadherins are key components in tissue morphogenesis and architecture, contributing to the establishment of cohesive cell adhesion. Reduced cellular adhesiveness as a result of cadherin dysfunction is a defining feature of cancer. During tumor development and progression, major changes in the glycan repertoire of cancer cells take place, affecting the stability, trafficking, and cell-adhesion properties of cadherins. Importantly, the different glycoforms of cadherins are promising biomarkers, with potential clinical application to improve the management of patients, and constitute targets for the development of new therapies. This review discusses the most recent insights on the impact of glycan structure on the regulation of cadherin function in cancer, and provides a perspective on how cadherin glycans constitute tumor biomarkers and potential therapeutic targets.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13