Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Willer, ASM (Autor) Outra; Santos Gomes, J (Autor) Outra; Adao, R (Autor) FMUP; Brás-Silva C (Autor) FMUP; Eyries, M (Autor) Outra; Perez Vizcaino, F (Autor) Outra; Capuano, V (Autor) Outra; Montani, D (Autor) Outra; Antigny, F (Autor) Outra

Revista

Título: JOURNAL OF PHYSIOLOGY-LONDON

Vol. 601

Páginas: 3717-3737

ISSN: 0022-3751

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 1 Citação

Classificação Científica

CORDIS: Ciências da Saúde

FOS: Ciências médicas e da saúde

Outras Informações

ID Authenticus: P-00Y-SRS

DOI: 10.1113/jp284936

Abstract (EN): Potassium channel subfamily K member 3 (KCNK3), encoded by the KCNK3 gene, is part of the two-pore domain potassium channel family, constitutively active at resting membrane potentials in excitable cells, including smooth muscle and cardiac cells. Several physiological and pharmacological mediators, such as intracellular signalling pathways, extracellular pH, hypoxia and anaesthetics, regulate KCNK3 channel function. Recent studies show that modulation of KCNK3 channel expression and function strongly influences pulmonary vascular cell and cardiomyocyte function. The altered activity of KCNK3 in pathological situations such as atrial fibrillation, pulmonary arterial hypertension and right ventricular dysfunction demonstrates the crucial role of KCNK3 in cardiovascular homeostasis. Furthermore, loss of function variants of KCNK3 have been identified in patients suffering from pulmonary arterial hypertension and atrial fibrillation. This review focuses on current knowledge of the role of the KCNK3 channel in pulmonary circulation and the heart, in healthy and pathological conditions.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 21