Impact of serum albumin concentration and neutrophil-lymphocyte ratio score on gastric cancer prognosis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Costa, T (Autor) Outra; Nogueiro, J (Autor) Outra; Ribeiro, D (Autor) Outra; Viegas, P (Autor) Outra; Santos Sousa, H (Autor) FMUP

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: LANGENBECKS ARCHIVES OF SURGERY

Vol. 408

ISSN: 1435-2443

Editora: Springer

Indexação

Scopus

Outras Informações

ID Authenticus: P-00X-TRK

DOI: 10.1007/s00423-023-02799-3

Abstract (EN): Introduction/aim: Serum albumin concentration (COA) and neutrophil¿lymphocyte ratio (NLR) could reflect immunological and nutritional status. We aim to evaluate the impact of COA-NLR score on the prognosis of gastric cancer (GC). Material and methods: We perform a retrospective analysis on a database of 637 GC cases, between January 2010 and December 2017. In 396 patients, the inclusion criteria for this study were met (non-resectional or palliative surgery were excluded). Analytic data was only available in 203 patients. COA-NLR score was defined as follows: COA under 35 g/L and NLR value of 2.585 or higher, score 2; one of these conditions, score 1; and neither, score 0. Results: In our population (n = 203), 87 patients were classified as score 0, 82 as score 1 and 34 as score 2. COA-NLR score was significantly associated with DFS (HR 1.674; CI 95% 1.115¿2.513; p = 0.013) and with OS (HR 2.072; CI 95% 1.531¿2.805; p < 0.001). Kaplan¿Meier curve analysis (log rank test) revealed that a higher score of COA-NLR predicted a worse OS (p < 0.001) and DFS (p = 0.03). COA-NLR was an independent prognostic factor for OS when adjusted to pStage and age (adjusted HR 1.566; CI 95% 1.145¿2.143; p = 0.005). Conclusions: Preoperative COA-NLR score was significantly associated with worse OS and DFS and, in this way, with worse prognosis on GC patients submitted to curative-intent resectional surgery. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Idioma: Inglês

Tipo (Avaliação Docente): Científica