Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2020

Autores

Catarata, MJ (Autor) Outra; Ribeiro, R (Autor) Outra; Oliveira, MJ (Autor) ICBAS; Robalo Cordeiro, CR (Autor) Outra; Rui Medeiros (Autor) ICBAS

Revista

Título: Cancers

Vol. 12

Páginas: 1-24

ISSN: 2072-6694

Editora: MDPI

Indexação

ISI Web of Knowledge - 34 Citações

Scopus - 34 Citações

Outras Informações

ID Authenticus: P-00S-9HZ

DOI: 10.3390/cancers12061457

Abstract (EN): The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 25